IL-21 Administration into the Nostril Alleviates Murine Allergic Rhinitis

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IL-21 administration into the nostril alleviates murine allergic rhinitis.

Type I allergic diseases such as allergic rhinitis are caused by IgE-mediated humoral immune responses, while eosinophils also fulfill important roles in the etiology of IgE-mediated allergy. IL-21 regulates growth, differentiation, and function of T, B, and NK cells, while the production of IgE is also influenced by IL-21. In this study we examined whether IL-21 is capable of controlling IgE-m...

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ژورنال

عنوان ژورنال: The Journal of Immunology

سال: 2007

ISSN: 0022-1767,1550-6606

DOI: 10.4049/jimmunol.179.10.7157